When Dr. MacKay first settled in Tamsui, he lived in the horse-stable-remodeled shabby home until 1874, until the Canada Presbyterian Church commissioned him to build two missionary dormitories. In 1875, Dr. MacKay designed and oversaw the construction of the dormitories located at today's Zhenli Street, materials were imported from Xiamen. The building was a white Spanish architecture with verandas on three sides, foundation elevated 4 feet above ground, and a high pitched roof to increases air circulation; practical for Taiwan's tropical climate and Tamsui's rainy weather.

This elegant establishment sits at Tamsui Puding (small hill) overlooking the Tamsui River and Guanyin Mountain. With its panoramic view and serene surroundings, the local students call it “the Little White House”. Japanese General Noji Maresuke once visited the site during the Meiji Period; Dr. MacKay lived here until his death.

During early World War II, MacKay's residence became a shelter home for women who lost their family. Later, it became Tamsui Middle School's student dormitory and then an armory near the end of the war.

After World War II, Bella Catherine MacKay (Dr. MacKay's youngest daughter), once lived in this residence. After the establishment of Tamsui Institute of Business Administration (precursor of today's Aletheia University) the residence became a dormitory for its English teachers. Today, the building is preserved and remains in good condition as part of Aletheia University's property, mostly reserved for the university president's use.